Drug interactions
Desipramine + Sufentanil sl
Severity: Moderate
Desipramine and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil and desipramine may both enhance serotonergic activity, so serotonin syndrome is possible though uncommon. The combination also adds CNS and respiratory depression.
What this interaction means in plain words
Desipramine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects (reuptake inhibition by desipramine) and additive CNS depression.
What to do
Observe for agitation, tremor, hyperreflexia, hyperthermia and diarrhea, especially at initiation and dose increases. Monitor sedation and respiratory status, and stop one agent if serotonin syndrome develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Sufentanil sl?
MediHelp rates the interaction as moderate. Desipramine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil and desipramine may both enhance serotonergic activity, so serotonin syndrome is possible though uncommon. The combination also adds CNS and respiratory depression.
How serious is the interaction between Desipramine and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe for agitation, tremor, hyperreflexia, hyperthermia and diarrhea, especially at initiation and dose increases. Monitor sedation and respiratory status, and stop one agent if serotonin syndrome develops.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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