Drug interactions
Desipramine + Sumatriptan intranasal
Severity: Moderate
Desipramine and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans and tricyclic antidepressants both affect serotonergic transmission, and serotonin syndrome has been reported with such combinations, though it is uncommon. Clinical risk is generally considered low.
What this interaction means in plain words
Desipramine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
5-HT1B/1D agonism from sumatriptan together with serotonin and noradrenaline reuptake inhibition from desipramine may produce additive serotonergic effects.
What to do
The combination can be used with awareness of the risk. Counsel patients to seek help for agitation, tremor, fever, sweating or diarrhoea, and avoid frequent dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Desipramine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans and tricyclic antidepressants both affect serotonergic transmission, and serotonin syndrome has been reported with such combinations, though it is uncommon. Clinical risk is generally considered low.
How serious is the interaction between Desipramine and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can be used with awareness of the risk. Counsel patients to seek help for agitation, tremor, fever, sweating or diarrhoea, and avoid frequent dosing.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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