Drug interactions
Desipramine + Thiothixene
Severity: Moderate
Desipramine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and can prolong the QT interval, raising the risk of arrhythmia. Anticholinergic effects and seizure threshold lowering may also be additive, and tricyclic levels may rise through CYP2D6 competition.
What this interaction means in plain words
Desipramine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, QTc prolongation and anticholinergic effects; possible pharmacokinetic competition at CYP2D6.
What to do
Obtain a baseline ECG and monitor QTc, especially in patients with cardiac risk factors. Monitor sedation and anticholinergic effects, and reduce doses if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desipramine and Thiothixene, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Thiothixene?
MediHelp rates the interaction as moderate. Desipramine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and can prolong the QT interval, raising the risk of arrhythmia. Anticholinergic effects and seizure threshold lowering may also be additive, and tricyclic levels may rise through CYP2D6 competition.
How serious is the interaction between Desipramine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, especially in patients with cardiac risk factors. Monitor sedation and anticholinergic effects, and reduce doses if they occur.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
