Drug interactions
Desipramine + Thyroid desiccated
Severity: Moderate
Desipramine and Thyroid desiccated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone can enhance the sensitivity of adrenergic receptors to tricyclic antidepressants, increasing the risk of tachycardia, arrhythmias and CNS stimulation. The same interaction is sometimes used deliberately to augment antidepressant response.
What this interaction means in plain words
Desipramine and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormone increases catecholamine receptor sensitivity, potentiating the cardiovascular and CNS effects of tricyclics.
What to do
Monitor heart rate, rhythm and mood, particularly in patients with cardiac disease or when doses change. Check thyroid function and adjust doses to avoid over-replacement.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Thyroid desiccated?
MediHelp rates the interaction as moderate. Desipramine and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone can enhance the sensitivity of adrenergic receptors to tricyclic antidepressants, increasing the risk of tachycardia, arrhythmias and CNS stimulation. The same interaction is sometimes used deliberately to augment antidepressant response.
How serious is the interaction between Desipramine and Thyroid desiccated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and mood, particularly in patients with cardiac disease or when doses change. Check thyroid function and adjust doses to avoid over-replacement.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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