Drug interactions
Desipramine + Topiramate
Severity: Moderate
Desipramine and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, cognitive slowing and dizziness, so the combination may increase impairment. Topiramate may also modestly alter tricyclic exposure, although this is generally not clinically important.
What this interaction means in plain words
Desipramine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depressant pharmacodynamic effects.
What to do
Titrate topiramate slowly and monitor for excessive sedation, confusion and impaired concentration. Advise caution with driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Topiramate
Frequently asked questions
Can I take Desipramine with Topiramate?
MediHelp rates the interaction as moderate. Desipramine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, cognitive slowing and dizziness, so the combination may increase impairment. Topiramate may also modestly alter tricyclic exposure, although this is generally not clinically important.
How serious is the interaction between Desipramine and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate topiramate slowly and monitor for excessive sedation, confusion and impaired concentration. Advise caution with driving and alcohol.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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