Drug interactions
Desipramine + Tropisetron
Severity: Moderate
Desipramine and Tropisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tropisetron, a 5-HT3 antagonist, may prolong the QT interval, and desipramine can do likewise. Concurrent use may increase the risk of arrhythmia, especially when other risk factors are present.
What this interaction means in plain words
Desipramine and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarisation. Tropisetron is also metabolised by CYP2D6, which desipramine can inhibit weakly.
What to do
Obtain an ECG in patients with cardiac disease or electrolyte abnormalities and correct potassium and magnesium. Consider an alternative antiemetic if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Tropisetron?
MediHelp rates the interaction as moderate. Desipramine and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tropisetron, a 5-HT3 antagonist, may prolong the QT interval, and desipramine can do likewise. Concurrent use may increase the risk of arrhythmia, especially when other risk factors are present.
How serious is the interaction between Desipramine and Tropisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with cardiac disease or electrolyte abnormalities and correct potassium and magnesium. Consider an alternative antiemetic if QTc is prolonged.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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