Drug interactions
Desipramine + Umeclidinium bromide / vilanterol inhaled
Severity: Major
Desipramine and Umeclidinium bromide / vilanterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of the beta-agonist vilanterol, including tachycardia, hypertension and QT prolongation. The risk is mainly relevant with chronic use and in patients with cardiac disease.
What this interaction means in plain words
Desipramine and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation and enhanced adrenergic cardiovascular stimulation by tricyclic-mediated norepinephrine reuptake blockade.
What to do
Use only if the benefit outweighs the risk, and monitor heart rate, blood pressure and ECG. Consider an alternative bronchodilator or antidepressant in patients with arrhythmia risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as major. Desipramine and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of the beta-agonist vilanterol, including tachycardia, hypertension and QT prolongation. The risk is mainly relevant with chronic use and in patients with cardiac disease.
How serious is the interaction between Desipramine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if the benefit outweighs the risk, and monitor heart rate, blood pressure and ECG. Consider an alternative bronchodilator or antidepressant in patients with arrhythmia risk.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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