Drug interactions
Desipramine + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Desipramine and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of inhaled vilanterol, including tachycardia, blood pressure rises and QT prolongation. Caution is stressed in patients with cardiac disease.
What this interaction means in plain words
Desipramine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and enhanced adrenergic stimulation from tricyclic blockade of norepinephrine reuptake.
What to do
Monitor heart rate, blood pressure and ECG, particularly in patients with cardiac risk factors. Consider an alternative inhaler or antidepressant if arrhythmia or marked tachycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Desipramine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of inhaled vilanterol, including tachycardia, blood pressure rises and QT prolongation. Caution is stressed in patients with cardiac disease.
How serious is the interaction between Desipramine and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, particularly in patients with cardiac risk factors. Consider an alternative inhaler or antidepressant if arrhythmia or marked tachycardia develops.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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