Drug interactions
Desipramine + Xylometazoline
Severity: Moderate
Desipramine and Xylometazoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine blocks norepinephrine reuptake and can potentiate pressor effects of sympathomimetics. Intranasal xylometazoline is poorly absorbed so effects are usually small, but hypertension or arrhythmia may occur with overuse.
What this interaction means in plain words
Desipramine and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Xylometazoline belongs to Respiratory.
Why it happens
Tricyclic inhibition of norepinephrine reuptake enhances adrenergic responses to vasoconstrictors.
What to do
Use xylometazoline at the lowest dose for a few days only. Monitor blood pressure and heart rate in patients with heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Xylometazoline
- Selegiline + Xylometazoline Contraindicated
- Ergotamine + Xylometazoline Major
- Isocarboxazid + Xylometazoline Major
- Phenelzine + Xylometazoline Major
- Tranylcypromine + Xylometazoline Major
- Amitriptyline + Xylometazoline Moderate
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Xylometazoline?
MediHelp rates the interaction as moderate. Desipramine and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine blocks norepinephrine reuptake and can potentiate pressor effects of sympathomimetics. Intranasal xylometazoline is poorly absorbed so effects are usually small, but hypertension or arrhythmia may occur with overuse.
How serious is the interaction between Desipramine and Xylometazoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use xylometazoline at the lowest dose for a few days only. Monitor blood pressure and heart rate in patients with heart disease.
What other medicines interact with Xylometazoline?
MediHelp also lists interactions of Xylometazoline with, for example, Selegiline, Ergotamine, Isocarboxazid. The full list is on the Xylometazoline page.
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