Drug interactions
Desogestrel-ethinyl estradiol + Diazepam
Severity: Minor
Desogestrel-ethinyl estradiol and Diazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives can reduce the clearance of diazepam, which is metabolized by CYP3A4 and CYP2C19, prolonging its effects. Increased sedation and psychomotor impairment may occur.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Diazepam belongs to Musculoskeletal.
Why it happens
Inhibition of oxidative (CYP-mediated) diazepam metabolism by ethinyl estradiol.
What to do
Monitor for excess sedation and reduce the diazepam dose if drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Diazepam
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Diazepam?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral contraceptives can reduce the clearance of diazepam, which is metabolized by CYP3A4 and CYP2C19, prolonging its effects. Increased sedation and psychomotor impairment may occur.
How serious is the interaction between Desogestrel-ethinyl estradiol and Diazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduce the diazepam dose if drowsiness occurs.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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