Drug interactions
Desogestrel-ethinyl estradiol + Istradefylline
Severity: Minor
Desogestrel-ethinyl estradiol and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At the higher 40 mg daily dose, istradefylline increases exposure to CYP3A4 substrates, which may raise ethinyl estradiol levels. This could increase estrogen-related adverse effects.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses inhibits CYP3A4, decreasing ethinyl estradiol metabolism.
What to do
No change is usually needed at 20 mg daily. If 40 mg daily is used, monitor for estrogenic adverse effects and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Istradefylline?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At the higher 40 mg daily dose, istradefylline increases exposure to CYP3A4 substrates, which may raise ethinyl estradiol levels. This could increase estrogen-related adverse effects.
How serious is the interaction between Desogestrel-ethinyl estradiol and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is usually needed at 20 mg daily. If 40 mg daily is used, monitor for estrogenic adverse effects and blood pressure.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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