Drug interactions
Desogestrel-ethinyl estradiol + Larotrectinib
Severity: Minor
Desogestrel-ethinyl estradiol and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with modest inhibitory potential, and a rise in ethinyl estradiol levels is theoretically possible. Clinical effect is probably small.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reduces ethinyl estradiol metabolism.
What to do
No routine adjustment needed. Monitor for estrogenic adverse effects, and note that effective contraception is needed because larotrectinib may harm the fetus.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Larotrectinib?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with modest inhibitory potential, and a rise in ethinyl estradiol levels is theoretically possible. Clinical effect is probably small.
How serious is the interaction between Desogestrel-ethinyl estradiol and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed. Monitor for estrogenic adverse effects, and note that effective contraception is needed because larotrectinib may harm the fetus.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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