Drug interactions
Desogestrel-ethinyl estradiol + Mavacamten
Severity: Major
Desogestrel-ethinyl estradiol and Mavacamten: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten may weakly induce CYP3A4 and lower ethinyl estradiol and progestin exposure. This may cause breakthrough bleeding or contraceptive failure.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desogestrel-ethinyl estradiol belongs to Endocrine; Mavacamten belongs to Cardiovascular.
Why it happens
CYP3A4 and other CYP induction by mavacamten increases hormone metabolism.
What to do
Use a contraceptive method not affected by enzyme induction, or add condoms, during treatment and for the period advised in the mavacamten labeling after stopping.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Mavacamten?
MediHelp rates the interaction as major. Desogestrel-ethinyl estradiol and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten may weakly induce CYP3A4 and lower ethinyl estradiol and progestin exposure. This may cause breakthrough bleeding or contraceptive failure.
How serious is the interaction between Desogestrel-ethinyl estradiol and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a contraceptive method not affected by enzyme induction, or add condoms, during treatment and for the period advised in the mavacamten labeling after stopping.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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