Drug interactions
Desogestrel-ethinyl estradiol + Nilotinib
Severity: Moderate
Desogestrel-ethinyl estradiol and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP3A4 inhibitor and might raise nilotinib exposure slightly. Because nilotinib prolongs the QT interval, any increase in its levels is a theoretical concern.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Ethinyl estradiol may weakly inhibit CYP3A4, reducing nilotinib metabolism.
What to do
Obtain an ECG and monitor electrolytes and QT interval as per nilotinib labeling, and review the contraceptive choice if QT prolongation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Nilotinib?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethinyl estradiol is a weak CYP3A4 inhibitor and might raise nilotinib exposure slightly. Because nilotinib prolongs the QT interval, any increase in its levels is a theoretical concern.
How serious is the interaction between Desogestrel-ethinyl estradiol and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and monitor electrolytes and QT interval as per nilotinib labeling, and review the contraceptive choice if QT prolongation occurs.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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