Drug interactions
Desogestrel-ethinyl estradiol + Ofloxacin
Severity: Minor
Desogestrel-ethinyl estradiol and Ofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin is not known to lower contraceptive hormone exposure in a clinically meaningful way. Contraceptive failure with fluoroquinolones has been suggested only theoretically.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
Why it happens
Theoretical disruption of gut flora involved in ethinyl estradiol enterohepatic recycling; not established clinically.
What to do
No additional contraception is routinely required; advise backup only if vomiting or severe diarrhea impairs pill absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Ofloxacin?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ofloxacin is not known to lower contraceptive hormone exposure in a clinically meaningful way. Contraceptive failure with fluoroquinolones has been suggested only theoretically.
How serious is the interaction between Desogestrel-ethinyl estradiol and Ofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No additional contraception is routinely required; advise backup only if vomiting or severe diarrhea impairs pill absorption.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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