Drug interactions
Desogestrel-ethinyl estradiol + Ropinirole
Severity: Moderate
Desogestrel-ethinyl estradiol and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens have been reported to reduce ropinirole clearance, raising its plasma levels. This may increase dopaminergic effects such as nausea, somnolence and orthostatic hypotension.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Ropinirole belongs to Central Nervous System.
Why it happens
Inhibition of CYP1A2-mediated ropinirole metabolism by estrogen.
What to do
Titrate ropinirole to clinical response and adjust the dose when estrogen is started or stopped; monitor for somnolence and hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Ropinirole?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogens have been reported to reduce ropinirole clearance, raising its plasma levels. This may increase dopaminergic effects such as nausea, somnolence and orthostatic hypotension.
How serious is the interaction between Desogestrel-ethinyl estradiol and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ropinirole to clinical response and adjust the dose when estrogen is started or stopped; monitor for somnolence and hypotension.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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