Drug interactions
Desvenlafaxine + Fesoterodine
Severity: Minor
Desvenlafaxine and Fesoterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine is a weak CYP2D6 inhibitor, and CYP2D6 contributes to clearance of fesoterodine's active metabolite. Increases in exposure are expected to be small and are unlikely to be clinically important at usual doses.
What this interaction means in plain words
Desvenlafaxine and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Fesoterodine belongs to Genitourinary.
Why it happens
Weak CYP2D6 inhibition slightly reduces clearance of the active metabolite of fesoterodine.
What to do
No dose change is generally required; monitor for anticholinergic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Fesoterodine?
MediHelp rates the interaction as minor. Desvenlafaxine and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desvenlafaxine is a weak CYP2D6 inhibitor, and CYP2D6 contributes to clearance of fesoterodine's active metabolite. Increases in exposure are expected to be small and are unlikely to be clinically important at usual doses.
How serious is the interaction between Desvenlafaxine and Fesoterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor for anticholinergic adverse effects.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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