Drug interactions
Desvenlafaxine + Galantamine
Severity: Minor
Desvenlafaxine and Galantamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine may slightly increase galantamine levels through CYP2D6 inhibition, potentially increasing nausea, vomiting and bradycardia. The effect is expected to be small.
What this interaction means in plain words
Desvenlafaxine and Galantamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Galantamine belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition reduces galantamine metabolism.
What to do
No routine adjustment is needed; monitor heart rate and gastrointestinal tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Desvenlafaxine with Galantamine?
MediHelp rates the interaction as minor. Desvenlafaxine and Galantamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desvenlafaxine may slightly increase galantamine levels through CYP2D6 inhibition, potentially increasing nausea, vomiting and bradycardia. The effect is expected to be small.
How serious is the interaction between Desvenlafaxine and Galantamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor heart rate and gastrointestinal tolerability.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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