Drug interactions
Desvenlafaxine + Ibrutinib
Severity: Moderate
Desvenlafaxine and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and carries a bleeding risk, and serotonin-norepinephrine reuptake inhibitors like desvenlafaxine also impair platelet aggregation. Together they may increase the chance of bruising or clinically significant bleeding.
What this interaction means in plain words
Desvenlafaxine and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Ibrutinib belongs to Oncology.
Why it happens
Additive impairment of platelet function (BTK inhibition by ibrutinib and reduced platelet serotonin with desvenlafaxine).
What to do
Monitor for signs of bleeding and check blood counts periodically. Review other antiplatelet or anticoagulant drugs and take extra care around procedures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Desvenlafaxine with Ibrutinib?
MediHelp rates the interaction as moderate. Desvenlafaxine and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and carries a bleeding risk, and serotonin-norepinephrine reuptake inhibitors like desvenlafaxine also impair platelet aggregation. Together they may increase the chance of bruising or clinically significant bleeding.
How serious is the interaction between Desvenlafaxine and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check blood counts periodically. Review other antiplatelet or anticoagulant drugs and take extra care around procedures.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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