Drug interactions
Desvenlafaxine + Nelfinavir
Severity: Minor
Desvenlafaxine and Nelfinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4, a minor elimination pathway of desvenlafaxine. Desvenlafaxine levels may increase modestly, with possible nausea, dizziness, or raised blood pressure. Clinical significance is generally limited.
What this interaction means in plain words
Desvenlafaxine and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Nelfinavir belongs to Anti Virals.
Why it happens
Inhibition of the minor CYP3A4 pathway of desvenlafaxine metabolism by nelfinavir.
What to do
Usually no adjustment is required. Monitor blood pressure and tolerability, and lower the desvenlafaxine dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Nelfinavir?
MediHelp rates the interaction as minor. Desvenlafaxine and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nelfinavir inhibits CYP3A4, a minor elimination pathway of desvenlafaxine. Desvenlafaxine levels may increase modestly, with possible nausea, dizziness, or raised blood pressure. Clinical significance is generally limited.
How serious is the interaction between Desvenlafaxine and Nelfinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no adjustment is required. Monitor blood pressure and tolerability, and lower the desvenlafaxine dose if adverse effects occur.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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