Drug interactions
Desvenlafaxine + Timolol
Severity: Minor
Desvenlafaxine and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine is a weak CYP2D6 inhibitor, and timolol is cleared partly through CYP2D6. Timolol exposure may rise modestly, with a greater risk of bradycardia or hypotension, mainly at higher desvenlafaxine doses. The effect is usually small at typical doses.
What this interaction means in plain words
Desvenlafaxine and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP2D6-mediated timolol metabolism by desvenlafaxine.
What to do
No routine dose change is needed. Monitor heart rate and blood pressure when desvenlafaxine is started or increased to high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Timolol?
MediHelp rates the interaction as minor. Desvenlafaxine and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desvenlafaxine is a weak CYP2D6 inhibitor, and timolol is cleared partly through CYP2D6. Timolol exposure may rise modestly, with a greater risk of bradycardia or hypotension, mainly at higher desvenlafaxine doses. The effect is usually small at typical doses.
How serious is the interaction between Desvenlafaxine and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor heart rate and blood pressure when desvenlafaxine is started or increased to high doses.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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