Drug interactions
Deutetrabenazine + Donepezil
Severity: Moderate
Deutetrabenazine and Donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil is associated with QT prolongation and bradycardia, while deutetrabenazine has little QT effect at recommended doses but may add to risk at higher exposure. Risk is mainly relevant with other risk factors such as electrolyte disturbance, bradycardia or CYP2D6 inhibitors.
What this interaction means in plain words
Deutetrabenazine and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Donepezil belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation.
What to do
Obtain an ECG in patients with QT risk factors and correct potassium and magnesium. Monitor for palpitations and syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Donepezil?
MediHelp rates the interaction as moderate. Deutetrabenazine and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil is associated with QT prolongation and bradycardia, while deutetrabenazine has little QT effect at recommended doses but may add to risk at higher exposure. Risk is mainly relevant with other risk factors such as electrolyte disturbance, bradycardia or CYP2D6 inhibitors.
How serious is the interaction between Deutetrabenazine and Donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with QT risk factors and correct potassium and magnesium. Monitor for palpitations and syncope.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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