Drug interactions
Deutetrabenazine + Esketamine
Severity: Moderate
Deutetrabenazine and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine can cause somnolence, sedation and depression. With esketamine, sedation may increase, and mood and suicidality should be watched in susceptible patients.
What this interaction means in plain words
Deutetrabenazine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression through pharmacodynamic effects.
What to do
Monitor sedation after esketamine dosing and monitor mood and suicidal ideation; reduce the deutetrabenazine dose if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Esketamine?
MediHelp rates the interaction as moderate. Deutetrabenazine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deutetrabenazine can cause somnolence, sedation and depression. With esketamine, sedation may increase, and mood and suicidality should be watched in susceptible patients.
How serious is the interaction between Deutetrabenazine and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation after esketamine dosing and monitor mood and suicidal ideation; reduce the deutetrabenazine dose if oversedation occurs.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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