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Drug interactions

Deutetrabenazine + Levosalbutamol

Severity: Minor

Deutetrabenazine and Levosalbutamol: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Deutetrabenazine causes a small QT effect at higher doses, and levosalbutamol can add to arrhythmic risk through tachycardia and lowered potassium. The clinical risk is modest but increases with electrolyte disturbance, bradycardia or other QT-prolonging drugs.

What this interaction means in plain words

Deutetrabenazine and Levosalbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Deutetrabenazine belongs to Central Nervous System; Levosalbutamol belongs to Respiratory.

Evidence level: Low

Why it happens

Possible additive effects on cardiac repolarization, with beta-2 agonist induced hypokalemia as a contributing factor.

What to do

Correct hypokalemia and hypomagnesemia and obtain an ECG in patients with additional QT risk factors. No dose change is routinely needed otherwise.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Deutetrabenazine with Levosalbutamol?

MediHelp rates the interaction as minor. Deutetrabenazine and Levosalbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deutetrabenazine causes a small QT effect at higher doses, and levosalbutamol can add to arrhythmic risk through tachycardia and lowered potassium. The clinical risk is modest but increases with electrolyte disturbance, bradycardia or other QT-prolonging drugs.

How serious is the interaction between Deutetrabenazine and Levosalbutamol?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypokalemia and hypomagnesemia and obtain an ECG in patients with additional QT risk factors. No dose change is routinely needed otherwise.

What other medicines interact with Levosalbutamol?

MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.

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