Drug interactions
Deutetrabenazine + Lithium
Severity: Moderate
Deutetrabenazine and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have some association with QT prolongation, though deutetrabenazine at recommended doses has little clinical effect on QT. Risk rises with bradycardia, electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Deutetrabenazine and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Lithium belongs to Central Nervous System.
Why it happens
Possible additive QTc prolongation.
What to do
Check baseline ECG and electrolytes in patients with other QT risk factors. Correct potassium and magnesium and monitor ECG if additional QT-prolonging drugs are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Lithium?
MediHelp rates the interaction as moderate. Deutetrabenazine and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have some association with QT prolongation, though deutetrabenazine at recommended doses has little clinical effect on QT. Risk rises with bradycardia, electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Deutetrabenazine and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with other QT risk factors. Correct potassium and magnesium and monitor ECG if additional QT-prolonging drugs are used.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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