Drug interactions
Deutetrabenazine + Octreotide
Severity: Moderate
Deutetrabenazine and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and deutetrabenazine has a small QT effect at higher exposures. Together they may add to arrhythmia risk, especially with bradycardia, electrolyte disturbance or other QT-prolonging drugs.
What this interaction means in plain words
Deutetrabenazine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Octreotide belongs to Endocrine.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check ECG and correct potassium and magnesium abnormalities in patients with additional risk factors. Avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Octreotide?
MediHelp rates the interaction as moderate. Deutetrabenazine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and deutetrabenazine has a small QT effect at higher exposures. Together they may add to arrhythmia risk, especially with bradycardia, electrolyte disturbance or other QT-prolonging drugs.
How serious is the interaction between Deutetrabenazine and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium abnormalities in patients with additional risk factors. Avoid adding further QT-prolonging drugs.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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