Drug interactions
Deutetrabenazine + Zolpidem
Severity: Moderate
Deutetrabenazine and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine can cause somnolence and sedation, and zolpidem may add to this effect. Patients may have impaired alertness and coordination, and deutetrabenazine also carries a depression risk that needs attention.
What this interaction means in plain words
Deutetrabenazine and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and central monoamine depletion by VMAT2 inhibition.
What to do
Use the lowest effective zolpidem dose and monitor for sedation and mood changes. Counsel patients on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Zolpidem?
MediHelp rates the interaction as moderate. Deutetrabenazine and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deutetrabenazine can cause somnolence and sedation, and zolpidem may add to this effect. Patients may have impaired alertness and coordination, and deutetrabenazine also carries a depression risk that needs attention.
How serious is the interaction between Deutetrabenazine and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective zolpidem dose and monitor for sedation and mood changes. Counsel patients on driving.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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