Drug interactions
Devil's claw + Diflunisal
Severity: Minor
Devil's claw and Diflunisal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Devil's claw has been reported to have antiplatelet activity and to raise bleeding risk in some patients on anticoagulants. Taken with diflunisal, which impairs platelet aggregation and can injure the GI mucosa, bleeding risk may rise.
What this interaction means in plain words
Devil's claw and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive antiplatelet effects; evidence is limited and largely theoretical.
What to do
Advise patients to report signs of bleeding and avoid adding other agents that affect hemostasis; monitor INR if on warfarin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Devil's claw with Diflunisal?
MediHelp rates the interaction as minor. Devil's claw and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Devil's claw has been reported to have antiplatelet activity and to raise bleeding risk in some patients on anticoagulants. Taken with diflunisal, which impairs platelet aggregation and can injure the GI mucosa, bleeding risk may rise.
How serious is the interaction between Devil's claw and Diflunisal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report signs of bleeding and avoid adding other agents that affect hemostasis; monitor INR if on warfarin.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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