Drug interactions
Devil's claw + Etodolac
Severity: Minor
Devil's claw and Etodolac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Devil's claw has reported antiplatelet activity and is itself used for pain, so combining it with etodolac may add to bleeding risk and gastrointestinal irritation. Evidence is limited to theoretical and case-level reports.
What this interaction means in plain words
Devil's claw and Etodolac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive platelet inhibition; not firmly established.
What to do
Advise avoiding duplicate analgesic therapy and report any bleeding or black stools. Take extra care if other anticoagulants are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Devil's claw and Etodolac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Devil's claw with Etodolac?
MediHelp rates the interaction as minor. Devil's claw and Etodolac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Devil's claw has reported antiplatelet activity and is itself used for pain, so combining it with etodolac may add to bleeding risk and gastrointestinal irritation. Evidence is limited to theoretical and case-level reports.
How serious is the interaction between Devil's claw and Etodolac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding duplicate analgesic therapy and report any bleeding or black stools. Take extra care if other anticoagulants are used.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
