Drug interactions
Devil's claw + Indomethacin
Severity: Minor
Devil's claw and Indomethacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Devil's claw has been linked with antiplatelet effects and rare bleeding reports, and indomethacin also increases bleeding tendency and GI mucosal injury. The combined risk is theoretical but plausible.
What this interaction means in plain words
Devil's claw and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive antiplatelet effect; evidence for devil's claw is limited.
What to do
Advise patients to report bruising, black stools or other bleeding. Avoid the combination in patients also taking anticoagulants or with a history of GI bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Devil's claw with Indomethacin?
MediHelp rates the interaction as minor. Devil's claw and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Devil's claw has been linked with antiplatelet effects and rare bleeding reports, and indomethacin also increases bleeding tendency and GI mucosal injury. The combined risk is theoretical but plausible.
How serious is the interaction between Devil's claw and Indomethacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report bruising, black stools or other bleeding. Avoid the combination in patients also taking anticoagulants or with a history of GI bleeding.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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