Drug interactions
Devil's claw + Ketoprofen
Severity: Minor
Devil's claw and Ketoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Devil's claw is reported to have possible antiplatelet effects and has been associated with bleeding in case reports. Added to ketoprofen, which impairs platelet aggregation and can injure the gastric mucosa, this may raise bleeding risk.
What this interaction means in plain words
Devil's claw and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive antiplatelet effects; the herb's activity is not well established.
What to do
Ask patients about herbal use and monitor for bruising or gastrointestinal bleeding; avoid in patients on anticoagulants or with ulcer history.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Devil's claw with Ketoprofen?
MediHelp rates the interaction as minor. Devil's claw and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Devil's claw is reported to have possible antiplatelet effects and has been associated with bleeding in case reports. Added to ketoprofen, which impairs platelet aggregation and can injure the gastric mucosa, this may raise bleeding risk.
How serious is the interaction between Devil's claw and Ketoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and monitor for bruising or gastrointestinal bleeding; avoid in patients on anticoagulants or with ulcer history.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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