Drug interactions
Devil's claw + Tolbutamide
Severity: Minor
Devil's claw and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Devil's claw has been reported in animal and traditional-use data to have glucose-lowering activity. Taken with tolbutamide, it could theoretically add to the hypoglycemic effect. Human evidence is lacking.
What this interaction means in plain words
Devil's claw and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive blood glucose lowering; mechanism is not established.
What to do
Advise patients to tell clinicians about herbal use and to monitor blood glucose for hypoglycemia if devil's claw is used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Devil's claw with Tolbutamide?
MediHelp rates the interaction as minor. Devil's claw and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Devil's claw has been reported in animal and traditional-use data to have glucose-lowering activity. Taken with tolbutamide, it could theoretically add to the hypoglycemic effect. Human evidence is lacking.
How serious is the interaction between Devil's claw and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to tell clinicians about herbal use and to monitor blood glucose for hypoglycemia if devil's claw is used regularly.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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