Drug interactions
Dexamethasone + Eprosartan-hydrochlorothiazide
Severity: Moderate
Dexamethasone and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic glucocorticoids and thiazide diuretics both cause potassium loss, so combined use may produce additive hypokalemia. Risk is greater with high doses or prolonged therapy and in patients with cardiac disease.
What this interaction means in plain words
Dexamethasone and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from thiazide action and glucocorticoid effects on the kidney.
What to do
Monitor serum potassium and magnesium and give replacement as needed during prolonged or high-dose dexamethasone therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Dexamethasone and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic glucocorticoids and thiazide diuretics both cause potassium loss, so combined use may produce additive hypokalemia. Risk is greater with high doses or prolonged therapy and in patients with cardiac disease.
How serious is the interaction between Dexamethasone and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and give replacement as needed during prolonged or high-dose dexamethasone therapy.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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