Drug interactions
Dexamethasone + Hydrochlorothiazide-telmisartan
Severity: Moderate
Dexamethasone and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazide diuretics and systemic corticosteroids cause potassium loss, so combined use increases the risk of hypokalemia. Corticosteroids may also raise blood pressure and fluid retention, opposing antihypertensive effect.
What this interaction means in plain words
Dexamethasone and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting and opposing effects on blood pressure and fluid balance.
What to do
Monitor serum potassium and blood pressure during courses of dexamethasone, and give potassium supplementation if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Dexamethasone and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazide diuretics and systemic corticosteroids cause potassium loss, so combined use increases the risk of hypokalemia. Corticosteroids may also raise blood pressure and fluid retention, opposing antihypertensive effect.
How serious is the interaction between Dexamethasone and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during courses of dexamethasone, and give potassium supplementation if needed.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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