Drug interactions
Dexamethasone + Larotrectinib
Severity: Moderate
Dexamethasone and Larotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and lower larotrectinib exposure, potentially reducing tumor control. The effect is weaker than with strong inducers such as rifampin.
What this interaction means in plain words
Dexamethasone and Larotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Larotrectinib belongs to Oncology.
Why it happens
Dexamethasone induces CYP3A4, increasing larotrectinib metabolism.
What to do
Use the lowest effective dexamethasone dose and monitor tumor response; avoid strong inducers and consider an alternative to prolonged dexamethasone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Dexamethasone with Larotrectinib?
MediHelp rates the interaction as moderate. Dexamethasone and Larotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may induce CYP3A4 and lower larotrectinib exposure, potentially reducing tumor control. The effect is weaker than with strong inducers such as rifampin.
How serious is the interaction between Dexamethasone and Larotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dexamethasone dose and monitor tumor response; avoid strong inducers and consider an alternative to prolonged dexamethasone.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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