Drug interactions
Dexamethasone + Lorlatinib
Severity: Moderate
Dexamethasone and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and dexamethasone is metabolized by CYP3A4, so dexamethasone exposure may fall. Lorlatinib itself is a CYP3A4 substrate, and dexamethasone may also reduce its levels. Reduced efficacy of either drug is possible.
What this interaction means in plain words
Dexamethasone and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Lorlatinib belongs to Oncology.
Why it happens
Mutual CYP3A4 induction and metabolism lowers exposure of both drugs.
What to do
Monitor for reduced steroid effect and adjust dexamethasone dose as needed. Monitor lorlatinib efficacy and liver enzymes during prolonged steroid use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Dexamethasone with Lorlatinib?
MediHelp rates the interaction as moderate. Dexamethasone and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a moderate CYP3A inducer and dexamethasone is metabolized by CYP3A4, so dexamethasone exposure may fall. Lorlatinib itself is a CYP3A4 substrate, and dexamethasone may also reduce its levels. Reduced efficacy of either drug is possible.
How serious is the interaction between Dexamethasone and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced steroid effect and adjust dexamethasone dose as needed. Monitor lorlatinib efficacy and liver enzymes during prolonged steroid use.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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