Drug interactions
Dexamethasone + Meclofenamic acid
Severity: Moderate
Dexamethasone and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids combined with NSAIDs raise the risk of peptic ulceration and gastrointestinal bleeding. The risk is greater with higher doses, longer courses and advanced age.
What this interaction means in plain words
Dexamethasone and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive gastric mucosal injury from NSAID prostaglandin inhibition and corticosteroid effects on mucosal protection and healing.
What to do
Limit dose and duration of both drugs and consider a proton pump inhibitor in at-risk patients. Monitor for GI bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Meclofenamic acid?
MediHelp rates the interaction as moderate. Dexamethasone and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids combined with NSAIDs raise the risk of peptic ulceration and gastrointestinal bleeding. The risk is greater with higher doses, longer courses and advanced age.
How serious is the interaction between Dexamethasone and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit dose and duration of both drugs and consider a proton pump inhibitor in at-risk patients. Monitor for GI bleeding symptoms.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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