Drug interactions
Dexamethasone + Pazopanib
Severity: Moderate
Dexamethasone and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is metabolized mainly by CYP3A4, which dexamethasone can induce. Pazopanib exposure may be reduced, potentially lowering antitumor effect.
What this interaction means in plain words
Dexamethasone and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Pazopanib belongs to Oncology.
Why it happens
Dexamethasone induces CYP3A4, increasing pazopanib clearance.
What to do
Monitor tumor response when prolonged dexamethasone is required. Avoid unnecessary long-term high-dose steroid use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Dexamethasone with Pazopanib?
MediHelp rates the interaction as moderate. Dexamethasone and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib is metabolized mainly by CYP3A4, which dexamethasone can induce. Pazopanib exposure may be reduced, potentially lowering antitumor effect.
How serious is the interaction between Dexamethasone and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response when prolonged dexamethasone is required. Avoid unnecessary long-term high-dose steroid use.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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