Drug interactions
Dexamethasone + Repaglinide
Severity: Moderate
Dexamethasone and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is metabolized by CYP2C8 and CYP3A4, and dexamethasone may induce CYP3A4, reducing repaglinide exposure. Dexamethasone also raises blood glucose directly. Both effects can reduce glycemic control.
What this interaction means in plain words
Dexamethasone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Dexamethasone induces CYP3A4 and causes steroid-induced hyperglycemia, opposing repaglinide effect.
What to do
Monitor blood glucose frequently during and after steroid therapy and adjust repaglinide dose accordingly. Watch for hypoglycemia when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Dexamethasone with Repaglinide?
MediHelp rates the interaction as moderate. Dexamethasone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repaglinide is metabolized by CYP2C8 and CYP3A4, and dexamethasone may induce CYP3A4, reducing repaglinide exposure. Dexamethasone also raises blood glucose directly. Both effects can reduce glycemic control.
How serious is the interaction between Dexamethasone and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during and after steroid therapy and adjust repaglinide dose accordingly. Watch for hypoglycemia when the steroid is tapered.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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