Drug interactions
Eslicarbazepine + Rilpivirine
Severity: Contraindicated
Eslicarbazepine and Rilpivirine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine can lower rilpivirine concentrations via CYP3A4 induction. This may cause loss of virologic suppression and NNRTI resistance.
What this interaction means in plain words
Eslicarbazepine and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eslicarbazepine belongs to Central Nervous System; Rilpivirine belongs to Anti Virals.
Why it happens
Eslicarbazepine induces CYP3A4, increasing the metabolism of rilpivirine.
What to do
Avoid the combination. Use a non-inducing antiseizure drug or an alternative antiretroviral regimen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Eslicarbazepine
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Eslicarbazepine with Rilpivirine?
MediHelp rates the interaction as contraindicated. Eslicarbazepine and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Eslicarbazepine can lower rilpivirine concentrations via CYP3A4 induction. This may cause loss of virologic suppression and NNRTI resistance.
How serious is the interaction between Eslicarbazepine and Rilpivirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use a non-inducing antiseizure drug or an alternative antiretroviral regimen.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Artemether / lumefantrine, Avapritinib. The full list is on the Eslicarbazepine page.
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