Drug interactions
Carbamazepine + Rilpivirine
Severity: Contraindicated
Carbamazepine and Rilpivirine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine substantially reduces rilpivirine concentrations, which may result in loss of virologic suppression and NNRTI resistance.
What this interaction means in plain words
Carbamazepine and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbamazepine belongs to Central Nervous System; Rilpivirine belongs to Anti Virals.
Why it happens
Carbamazepine induces CYP3A4, increasing rilpivirine clearance.
What to do
Do not combine; use an alternative anticonvulsant such as levetiracetam or change the antiretroviral regimen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Rilpivirine
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Carbamazepine with Rilpivirine?
MediHelp rates the interaction as contraindicated. Carbamazepine and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine substantially reduces rilpivirine concentrations, which may result in loss of virologic suppression and NNRTI resistance.
How serious is the interaction between Carbamazepine and Rilpivirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative anticonvulsant such as levetiracetam or change the antiretroviral regimen.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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