Drug interactions
Dexamethasone + Sotorasib
Severity: Minor
Dexamethasone and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-glycoprotein inhibitor and dexamethasone is a P-gp substrate, so dexamethasone exposure could rise modestly. Sotorasib is also a weak CYP3A4 inducer, which could lower dexamethasone exposure, so the net effect is uncertain. The clinical impact is generally limited.
What this interaction means in plain words
Dexamethasone and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone belongs to Endocrine; Sotorasib belongs to Oncology.
Why it happens
Sotorasib inhibits P-gp and may weakly induce CYP3A4, so it can alter dexamethasone exposure in either direction.
What to do
No routine dose change is needed. Monitor for corticosteroid adverse effects or reduced steroid effect when treatment is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Dexamethasone with Sotorasib?
MediHelp rates the interaction as minor. Dexamethasone and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib is a P-glycoprotein inhibitor and dexamethasone is a P-gp substrate, so dexamethasone exposure could rise modestly. Sotorasib is also a weak CYP3A4 inducer, which could lower dexamethasone exposure, so the net effect is uncertain. The clinical impact is generally limited.
How serious is the interaction between Dexamethasone and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for corticosteroid adverse effects or reduced steroid effect when treatment is started or stopped.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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