Drug interactions
Dexamethasone + Tolmetin
Severity: Moderate
Dexamethasone and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic dexamethasone with an NSAID raises the risk of peptic ulcer disease and gastrointestinal bleeding. The risk rises with higher doses, prolonged therapy and advanced age.
What this interaction means in plain words
Dexamethasone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive gastric mucosal injury from NSAID prostaglandin inhibition and corticosteroid impairment of mucosal repair.
What to do
Limit duration and dose of both drugs and add a proton pump inhibitor in at-risk patients. Monitor for GI symptoms and bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Tolmetin?
MediHelp rates the interaction as moderate. Dexamethasone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic dexamethasone with an NSAID raises the risk of peptic ulcer disease and gastrointestinal bleeding. The risk rises with higher doses, prolonged therapy and advanced age.
How serious is the interaction between Dexamethasone and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit duration and dose of both drugs and add a proton pump inhibitor in at-risk patients. Monitor for GI symptoms and bleeding.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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