Drug interactions
Dexamethasone + Vandetanib
Severity: Moderate
Dexamethasone and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib is metabolized by CYP3A4, and inducers such as dexamethasone may lower exposure and efficacy. Dexamethasone is a weaker inducer than agents like rifampicin.
What this interaction means in plain words
Dexamethasone and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Vandetanib belongs to Oncology.
Why it happens
Dexamethasone induces CYP3A4, increasing vandetanib clearance.
What to do
Avoid prolonged dexamethasone where possible; if needed, monitor treatment response and QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Dexamethasone with Vandetanib?
MediHelp rates the interaction as moderate. Dexamethasone and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib is metabolized by CYP3A4, and inducers such as dexamethasone may lower exposure and efficacy. Dexamethasone is a weaker inducer than agents like rifampicin.
How serious is the interaction between Dexamethasone and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged dexamethasone where possible; if needed, monitor treatment response and QTc.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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