Drug interactions
Dexamethasone-neomycin-polymyxin + Ibrutinib
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A inducers markedly reduce ibrutinib exposure, but dexamethasone is only a weak to moderate inducer. Systemic dexamethasone may modestly lower ibrutinib levels, and topical use has minimal effect.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Ibrutinib belongs to Oncology.
Why it happens
CYP3A4 induction by dexamethasone increases ibrutinib metabolism.
What to do
With systemic dexamethasone, monitor for reduced ibrutinib response. No action is needed for topical use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Ibrutinib?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A inducers markedly reduce ibrutinib exposure, but dexamethasone is only a weak to moderate inducer. Systemic dexamethasone may modestly lower ibrutinib levels, and topical use has minimal effect.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, monitor for reduced ibrutinib response. No action is needed for topical use.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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