Drug interactions
Dexamethasone-neomycin-polymyxin + Istradefylline
Severity: Minor
Dexamethasone-neomycin-polymyxin and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg/day can inhibit CYP3A4 and P-glycoprotein and may raise dexamethasone exposure. The effect is relevant mainly with systemic dexamethasone.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline inhibits CYP3A4 and P-glycoprotein at higher doses, reducing dexamethasone clearance.
What to do
Monitor for corticosteroid adverse effects with systemic dexamethasone. Consider reducing the dexamethasone dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Istradefylline
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Istradefylline?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at 40 mg/day can inhibit CYP3A4 and P-glycoprotein and may raise dexamethasone exposure. The effect is relevant mainly with systemic dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects with systemic dexamethasone. Consider reducing the dexamethasone dose if they appear.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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