Drug interactions
Dexamethasone-neomycin-polymyxin + Ketoconazole
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole strongly inhibits CYP3A4 and can raise systemic dexamethasone exposure, increasing risk of corticosteroid adverse effects and adrenal suppression. It also inhibits adrenal steroid synthesis. Topical use of the combination product yields little systemic exposure.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Ketoconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 by ketoconazole reduces dexamethasone clearance.
What to do
With systemic dexamethasone, consider dose reduction and monitor for Cushingoid effects and hyperglycemia. No change is usually needed for short topical use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Ketoconazole?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole strongly inhibits CYP3A4 and can raise systemic dexamethasone exposure, increasing risk of corticosteroid adverse effects and adrenal suppression. It also inhibits adrenal steroid synthesis. Topical use of the combination product yields little systemic exposure.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, consider dose reduction and monitor for Cushingoid effects and hyperglycemia. No change is usually needed for short topical use.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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