Drug interactions
Dexamethasone-neomycin-polymyxin + Levonorgestrel
Severity: Minor
Dexamethasone-neomycin-polymyxin and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and lower levonorgestrel exposure. The clinical importance is uncertain with short courses, but contraceptive efficacy could be reduced with prolonged use.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Levonorgestrel belongs to Endocrine.
Why it happens
Possible CYP3A4 induction by dexamethasone accelerating levonorgestrel metabolism.
What to do
No change is usually needed for short courses. With prolonged systemic dexamethasone, consider additional barrier contraception.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Levonorgestrel?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone may induce CYP3A4 and lower levonorgestrel exposure. The clinical importance is uncertain with short courses, but contraceptive efficacy could be reduced with prolonged use.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is usually needed for short courses. With prolonged systemic dexamethasone, consider additional barrier contraception.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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