Drug interactions
Dexamethasone-neomycin-polymyxin + Lorlatinib
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a CYP3A4 inducer and may reduce dexamethasone exposure. In addition, dexamethasone, as a CYP3A4 inducer, may lower lorlatinib levels, and concomitant strong inducers are restricted in labeling because of reduced efficacy and hepatotoxicity concerns.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Lorlatinib belongs to Oncology.
Why it happens
Mutual CYP3A4 induction accelerates metabolism of dexamethasone and lorlatinib.
What to do
Monitor clinical response to dexamethasone and consider dose adjustment. Monitor liver enzymes and lorlatinib effectiveness if systemic dexamethasone is used long term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Lorlatinib?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a CYP3A4 inducer and may reduce dexamethasone exposure. In addition, dexamethasone, as a CYP3A4 inducer, may lower lorlatinib levels, and concomitant strong inducers are restricted in labeling because of reduced efficacy and hepatotoxicity concerns.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to dexamethasone and consider dose adjustment. Monitor liver enzymes and lorlatinib effectiveness if systemic dexamethasone is used long term.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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