Drug interactions
Dexamethasone-neomycin-polymyxin + Meloxicam
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concomitant corticosteroid and NSAID use increases the risk of peptic ulcers and GI bleeding. Meloxicam is relatively COX-2 preferential at low doses but the risk remains.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Meloxicam belongs to Musculoskeletal.
Why it happens
Additive mucosal injury from corticosteroids and NSAID-mediated prostaglandin inhibition.
What to do
Use the lowest effective doses and consider a proton pump inhibitor in patients at GI risk. Monitor for bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Meloxicam?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concomitant corticosteroid and NSAID use increases the risk of peptic ulcers and GI bleeding. Meloxicam is relatively COX-2 preferential at low doses but the risk remains.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and consider a proton pump inhibitor in patients at GI risk. Monitor for bleeding signs.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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